Scientists at The Scripps Research Institute (TSRI) have discovered that a brain protein has a key role in controlling binge drinking in animal models. They found that deleting the gene for this protein in mice ramped up alcohol consumption and prevented the brain from signaling the rewarding properties of alcohol.
"Alcohol hits a lot of different targets in our brain, which makes disentangling the in vivo effects of alcohol quite complicated," said TSRI biologist Candice Contet, senior author of the study. "Our study sheds light on the molecular mechanisms implicated in binge drinking."
Researchers have uncovered a unique connection between diabetes and Alzheimer's disease, providing further evidence that a disease that robs people of their memories may be affected by elevated blood sugar, according to scientists at Washington University School of Medicine in St. Louis.
While many earlier studies have pointed to diabetes as a possible contributor to Alzheimer's, the new study - in mice - shows that elevated glucose in the blood can rapidly increase levels of amyloid beta, a key component of brain plaques in Alzheimer's patients. The buildup of plaques is thought to be an early driver of the complex set of changes that Alzheimer's causes in the brain. The research is published May 4 in The Journal of Clinical Investigation.
A University of Cincinnati (UC)-led research team has found that generic formulations of tacrolimus, a drug used post-transplant to lower the risk of organ rejection, are just as good as the name-brand version.
The findings were presented Sunday, May 3, by lead investigator Rita Alloway, PharmD, UC research professor of medicine and director of transplant clinical research within the UC Department of Internal Medicine, and her study collaborators at the 2015 American Transplant Congress annual meeting in Philadelphia.
Young children with autism spectrum disorder, who also have serious behavioral problems, showed improved behavior when their parents were trained with specific, structured strategies to manage tantrums, aggression, self-injury, and non-compliance. The findings from this parent training study by Yale and Emory University researchers were published recently in the Journal of the American Medical Association (JAMA).
This 24-week, multisite, randomized trial was conducted by the Research Units on Behavioral Intervention (RUBI) Autism Network, a six-site National Institute of Mental Health-funded consortium dedicated to developing and testing behavioral treatments for children with ASD.
Lung cancer patients who used statins in the year prior to a lung cancer diagnosis or after a lung cancer diagnosis had a reduction in the risk of death from the disease.
Recently there has been much interest in the potential for exploring new therapeutic uses for existing drugs, in part, because existing medications are relatively inexpensive and have known side effect profiles, according to Cardwell. This study investigated whether lung cancer patients who received statins had improved cancer outcomes.Cardwell and colleagues used data from nearly 14,000 patients newly diagnosed with lung cancer between 1998 and 2009 from English cancer registry data. They gathered the patients' prescription records from the U.K. Clinical Practice Research Datalink and mortality data up to 2012 from the Office of National Statistics.
Researchers at University of California San Diego School of Medicine report pancreatic cancer rates are highest in countries with the least amount of sunlight. Low sunlight levels were due to a combination of heavy cloud cover and high latitude.
"If you're living at a high latitude or in a place with a lot of heavy cloud cover, you can't make vitamin D most of the year, which results in a higher-than-normal risk of getting pancreatic cancer," said first author Cedric F. Garland, DrPH, adjunct professor in the Department of Family Medicine and Public Health and member of UC San Diego Moores Cancer Center. "People who live in sunny countries near the equator have only one-sixth of the age-adjusted incidence rate of pancreatic cancer as those who live far from it. The importance of sunlight deficiency strongly suggests - but does not prove - that vitamin D deficiency may contribute to risk of pancreatic cancer."